I can find plenty of information on congenital heart disease and plenty of information on cell signaling/signal transduction but i cant find out how they are related can anyone help?
Heart Diseases - 1 Answers
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In some cases of congenital heart disease there are physical malformations that can cause electrical signals from one area of the heart to another area to be attenuated or timed incorrectly. The signal transduction pathway may be operating at the cellular level as it should. If the signals received to initiate the complex process are weak or not timed properly the resulting release of glucose to power the heart muscle may not be sufficient to sustain normal heart function. Muscle contractions may be either weak or not timed properly to co-ordinate with other heart muscles. In some cases there may be a lack of sufficient amount of a particular enzyme which may result in the signal transduction pathway within the cell to function improperly. As you may be aware from your research, normal heart function is a very complex process involving a great number of steps which all must take place in proper sequence. The number of steps within the cell alone are very complex. I hope that gives you some insight on the subject
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