has anyone done a study to determine how hormone therapy has affected transgender people? I would like to know if estrogen shots could benefit people with heart disease?
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Interesting question... We do know that estrogen has cardioprotective effects (testosterone does not specifically have negative effects on the heart, it just lacks the protective effects.) Among young otherwise healthy women who've had radical hysterectomies ("surgical menopause") the hormone replacement therapy (HRT) still provides the cardioprotective effects. After natural menopause, long term estrogen-only HRT is linked with gynecologic cancers. (Note: Including progesterone in HRT for post-menopausal women helps prevent the increased cancer risk.) As I'm sure you're aware, the transgendered population is unfortunately under-represented in scientific studies. But we can extrapolate the data above to very reasonably infer that trasgendered individuals who receive HRT also would benefit from the cardiovascular "protection" of estrogen. All of that said, while estrogen has cardioprotective effects it is generally not considered any kind of "treatment" for cardiovascular disease. (Not sure if that was what you were asking?) We don't take hormone treatment lightly, because the interplay/feedback mechanisms among hormones are in delicate balance. So any time you include hormone therapy in a protocol, you have to be aware of (and manage) the trickle-down effects you'll have on the multitude of systems throughout the body
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